Low glucose and serum levels cause an increased inflammatory factor in 3T3-L1 cell through Akt, MAPKs and NF-?B activation

Abdominal aortic aneurysm (AAA) involves the degradation of vascular fibres, and dilation rupture abdominal aorta. Hypoperfusion in walls due to stenosis vasa vasorum is reportedly a cause AAA onset induction adventitial ectopic adipocytes. Recent studies have reported that adipocytes are associated with both human hypoperfusion-induced animal models, highlighting pathological importance hypoperfusion AAA. However, relationship between remains unknown. In this study, we investigated changes inflammation-related factors at low glucose serum levels. Low levels enhanced production AAA-related 3T3-L1 cells. increased activation protein kinase B (also known as Akt), extracellular signal-regulated 1/2, p38, c-Jun N-terminal kinase, nuclear factor (NF) ?B level. The inflammatory related signalling pathways were markedly decreased following return cells normal culture conditions. These data suggest increase through Akt, mitogen activated NF-?B pathways.